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| Hydrophobic gray pocket in TYK2 pseudokinase domain Wrobleski et. al. (2019) |
My day to day struggles for being a better software developer, medicinal chemist and computational chemist.. ðŸ«
Learning to design.. baby steps
While reading about the recent advancements for TYK2 inhibitors, I came across this article by Matsumoto et.al. (2025) and started wondering how did they synthesize such molecules? Of course its pre-cursor Deucravacitinib aka BMS-986165, had a fascinating story itself (Wrobleski et. al.(2019) but that's for another day..) and I started reading about the synthesis part casually and went into deep slumber of thoughts.
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